GHRP-2
Growth Hormone Releasing Peptide-2 (Pralmorelin)
Mechanism of Action
Synthetic pentapeptide ghrelin receptor (GHSR-1a) agonist. More potent and selective GH secretagogue than GHRP-6, with comparatively weaker orexigenic (appetite) signaling through the same hypothalamic-pituitary GH axis.
Key Benefits
- Strong, reliable GH pulse
- Less appetite stimulation than GHRP-6
- Improved body composition and recovery
- Sleep quality support
Dosing Protocol
Used as pralmorelin in a formal clinical GH-stimulation test (paired with GHRH) to diagnose GH deficiency, giving GHRP-2 a stronger human PK dataset than most other GHRPs. Commonly stacked with a GHRH analog.
Ideal Candidates
GH optimization, body recomposition, users who want GH secretagogue effects without strong appetite stimulation.
Side Effects & Safety
Water retention, mild cortisol and prolactin elevation, injection site reactions, transient hunger (milder than GHRP-6).
Regulatory Status
RestrictedFDA Category 2 — on the do-not-compound list. Used clinically outside the US as a GH-deficiency diagnostic agent (pralmorelin).
Evidence & Citations
- Bercu BB, Walker RF. Growth hormone secretagogues in children with altered growth. Acta Paediatr Suppl. 1997;423:102-6.
- Okano M, et al. Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by LC/ESI tandem mass spectrometry. Rapid Commun Mass Spectrom. 2010;24(14):2046-56.
- Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45-53.
Frequently asked
What is GHRP-2?+
GHRP-2 (Growth Hormone Releasing Peptide-2 (Pralmorelin)) is a peptide studied for gh secretagogue and higher potency. Synthetic pentapeptide ghrelin receptor (GHSR-1a) agonist. More potent and selective GH secretagogue than GHRP-6, with comparatively weaker orexigenic (appetite) signaling through the same hypothalamic-pituitary GH axis.
What is the dosing protocol for GHRP-2?+
Literature commonly references 100 mcg/dose (low) to 200–300 mcg/dose (maintenance) via SubQ, 2–3x daily, on a 8–12 weeks cycle. Educational reference only — a licensed Stackhaus Health provider sets any personalized protocol.
What is the regulatory status of GHRP-2?+
FDA Category 2 — on the do-not-compound list. Used clinically outside the US as a GH-deficiency diagnostic agent (pralmorelin).
Where can I access GHRP-2?+
Research-grade GHRP-2 is available through Stackhaus Research. For a personalized, provider-reviewed protocol, consult a licensed clinician through Stackhaus Health.