GHRP-6
Growth Hormone Releasing Peptide-6
Mechanism of Action
Hexapeptide ghrelin receptor (GHSR-1a) agonist. Activates the same G-protein-coupled receptor as endogenous ghrelin in the hypothalamus and pituitary, triggering pulsatile GH release and, via the same hypothalamic pathway, a pronounced increase in appetite and food intake.
Key Benefits
- GH pulse stimulation
- Significant appetite increase
- Improved recovery and sleep
- Lean mass support during caloric surplus
Dosing Protocol
Appetite stimulation is dose-dependent and often the limiting factor — inject away from meals if hunger is unwanted. Frequently stacked with a GHRH analog (e.g., CJC-1295) for synergistic GH pulse amplification.
Ideal Candidates
Bulking phases, underweight individuals, GH optimization where appetite stimulation is desirable.
Side Effects & Safety
Pronounced hunger/appetite increase, water retention, mild cortisol and prolactin elevation, injection site reactions, tingling/numbness in extremities.
Regulatory Status
RestrictedFDA Category 2 — on the do-not-compound list. One of the original synthetic GH secretagogues; educational reference only.
Evidence & Citations
- Bowers CY. History to the discovery of ghrelin. Methods Enzymol. 2012;514:3-32.
- Gertz BJ, et al. Growth hormone response in man to L-692,429, a novel nonpeptide mimic of growth hormone-releasing peptide-6. J Clin Endocrinol Metab. 1993;77(5):1393-7.
- Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018;6(1):45-53.
Frequently asked
What is GHRP-6?+
GHRP-6 (Growth Hormone Releasing Peptide-6) is a peptide studied for gh secretagogue and appetite stimulation. Hexapeptide ghrelin receptor (GHSR-1a) agonist. Activates the same G-protein-coupled receptor as endogenous ghrelin in the hypothalamus and pituitary, triggering pulsatile GH release and, via the same hypothalamic pathway, a pronounced increase in appetite and food intake.
What is the dosing protocol for GHRP-6?+
Literature commonly references 100 mcg/dose (low) to 200–300 mcg/dose (maintenance) via SubQ, 2–3x daily, on a 8–12 weeks cycle. Educational reference only — a licensed Stackhaus Health provider sets any personalized protocol.
What is the regulatory status of GHRP-6?+
FDA Category 2 — on the do-not-compound list. One of the original synthetic GH secretagogues; educational reference only.
Where can I access GHRP-6?+
Research-grade GHRP-6 is available through Stackhaus Research. For a personalized, provider-reviewed protocol, consult a licensed clinician through Stackhaus Health.