Hexarelin
Hexarelin (Examorelin)
Mechanism of Action
Synthetic hexapeptide GH secretagogue that activates both the ghrelin receptor (GHSR-1a) for GH release and the non-GHSR scavenger receptor CD36 in cardiac tissue, the latter mediating GH-independent cardioprotective effects against ischemia-reperfusion injury.
Key Benefits
- Most potent GH pulse of the GHRP class
- GH-independent cardioprotection (preclinical)
- Improved body composition and recovery
- Anti-inflammatory signaling in cardiac tissue (preclinical)
Dosing Protocol
Most potent but least selective GHRP — desensitizes quickly, so cycles are kept short (4–8 weeks) with breaks. Cardioprotective data is preclinical (rodent) and GH-independent via CD36.
Ideal Candidates
Experienced users seeking maximal GH secretagogue potency; short cycles due to desensitization.
Side Effects & Safety
More pronounced cortisol and prolactin elevation than other GHRPs, water retention, injection site reactions, rapid receptor desensitization ("hexarelin burnout") with continuous use.
Regulatory Status
RestrictedFDA Category 2 — on the do-not-compound list. Educational reference only.
Evidence & Citations
- Mao Y, Tokudome T, Kishimoto I. The cardiovascular action of hexarelin. J Geriatr Cardiol. 2014;11(3):253-8.
- Locatelli V, et al. Growth hormone-independent cardioprotective effects of hexarelin in the rat. Endocrinology. 1999;140(9):4024-31.
- Huang J, et al. The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway. Int Heart J. 2017;58(2):257-263.
Frequently asked
What is Hexarelin?+
Hexarelin (Hexarelin (Examorelin)) is a peptide studied for most potent ghrp and cardioprotective. Synthetic hexapeptide GH secretagogue that activates both the ghrelin receptor (GHSR-1a) for GH release and the non-GHSR scavenger receptor CD36 in cardiac tissue, the latter mediating GH-independent cardioprotective effects against ischemia-reperfusion injury.
What is the dosing protocol for Hexarelin?+
Literature commonly references 100 mcg/dose (low) to 200 mcg/dose (maintenance) via SubQ, 1–3x daily, on a 4–8 weeks cycle. Educational reference only — a licensed Stackhaus Health provider sets any personalized protocol.
What is the regulatory status of Hexarelin?+
FDA Category 2 — on the do-not-compound list. Educational reference only.
Where can I access Hexarelin?+
Research-grade Hexarelin is available through Stackhaus Research. For a personalized, provider-reviewed protocol, consult a licensed clinician through Stackhaus Health.